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Submit ReviewCBiPES hydrochloride
Discontinued Product
3949 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Positive allosteric modulator of mGlu2 receptors
Chemical Name: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for CBiPES hydrochloride
Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.
Technical Data for CBiPES hydrochloride
| M. Wt | 413.92 |
| Formula | C21H19N3O2S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 856702-40-4 |
| PubChem ID | 71532792 |
| InChI Key | QKUHSVQWWZBAKM-UHFFFAOYSA-N |
| Smiles | O=S(N(CC2=CC=CN=C2)C1=CC(C3=CC=C(C#N)C=C3)=CC=C1)(CC)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CBiPES hydrochloride
References for CBiPES hydrochloride
References are publications that support the biological activity of the product.
Johnson et al (2005) Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 179 271 PMID: 15717213
Fell et al (2010) Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute KA challenge. Neuropharmacology. 58 632 PMID: 19951716
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Keywords: CBiPES hydrochloride, CBiPES hydrochloride supplier, positive, allosteric, modulators, PAMs, mGlu2, mGluR2, metabotropic, glutamate, group, II, receptors, Glutamate, (Metabotropic), Group, Receptors, 3949, Tocris Bioscience
1 Citation for CBiPES hydrochloride
Citations are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:
Yin et al (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34 79 PMID: 24381270
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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