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Submit ReviewCBM 301940
Description: Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Chemical Name: tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
Purity: ≥98% (HPLC)
Biological Activity for CBM 301940
CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.
Compound Libraries for CBM 301940
CBM 301940 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CBM 301940
| M. Wt | 422.32 |
| Formula | C15H20F6N2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 902146-11-6 |
| PubChem ID | 10387489 |
| InChI Key | SBPVPWWNQIKSKL-UHFFFAOYSA-N |
| Smiles | CC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CBM 301940
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.23 | 100 | |
| ethanol | 42.23 | 100 |
Preparing Stock Solutions for CBM 301940
The following data is based on the product molecular weight 422.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.68 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for CBM 301940
References for CBM 301940
References are publications that support the biological activity of the product.
Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID: 15105298
Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID: 16821767
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Keywords: CBM 301940, CBM 301940 supplier, CBM301940, MCD, malonyl, coenzyme, A, CoA, inhibitors, inhibits, potent, orally, bioavailable, Decarboxylases, Other, Lipid, Metabolism, 6319, Tocris Bioscience
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