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CBR 5884

Cat. No. 5836 2 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

5836 has been discontinued.

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Description: Phosphoglycerate dehydrogenase (PHGDH) inhibitor
Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for CBR 5884

CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data for CBR 5884

M. Wt 336.39
Formula C14H12N2O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 681159-27-3
PubChem ID 4674993
InChI Key QBVIRPJBDIZKBC-UHFFFAOYSA-N
Smiles CCOC(C1=C(C(SC#N)=C(S1)NC(C2=CC=CO2)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CBR 5884

References are publications that support the biological activity of the product.

Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078

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Keywords: CBR 5884, CBR 5884 supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Other, Dehydrogenases, 5836, Tocris Bioscience

2 Citations for CBR 5884

Citations are publications that use Tocris products. Selected citations for CBR 5884 include:

Nigdelioglu et al (2016) Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem 291 27239 PMID: 27836973

Sen et al (2018) EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57 1342 PMID: 29873416

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.