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Submit ReviewCCF 642
Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Biological Activity for CCF 642
CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.
Technical Data for CCF 642
| M. Wt | 378.45 |
| Formula | C15H10N2O4S3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 346640-08-2 |
| PubChem ID | 1820764 |
| InChI Key | SPYIETQLOVDJCF-XYOKQWHBSA-N |
| Smiles | COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CCF 642
References for CCF 642
References are publications that support the biological activity of the product.
Vatolin et al (2016) Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76 3340 PMID: 27197150
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Keywords: CCF 642, CCF 642 supplier, CCF642, protein, disulfide, isomerases, PDI, inhibitors, inhibits, cancer, multiple, myeloma, cells, Protein, Disulfide, Isomerase, 6063, Tocris Bioscience
Citations for CCF 642
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Gut Hormones Poster
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.