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Submit ReviewCD 437
Description: RARγ-selective agonist
Alternative Names: AHPN
Chemical Name: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for CD 437
CD 437 is a synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.
Compound Libraries for CD 437
CD 437 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for CD 437
| M. Wt | 398.5 |
| Formula | C27H26O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 125316-60-1 |
| PubChem ID | 135411 |
| InChI Key | LDGIHZJOIQSHPB-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=CC=C2C=C(C=CC2=C1)C1=CC=C(O)C(=C1)C12CC3CC(CC(C3)C1)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CD 437
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 7.97 | 20 | |
| DMSO | 39.85 | 100 |
Preparing Stock Solutions for CD 437
The following data is based on the product molecular weight 398.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.09 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for CD 437
References for CD 437
References are publications that support the biological activity of the product.
Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44 PMID: 12566985
Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283 PMID: 21990348
If you know of a relevant reference for CD 437, please let us know.
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Keywords: CD 437, CD 437 supplier, RARγ, RARgamma-selective, agonists, RAR, RAMBA, Retinoic, Acid, Receptors, peroxisome, proliferator-activating, CD437, AHPN, 1549, Tocris Bioscience
4 Citations for CD 437
Citations are publications that use Tocris products. Selected citations for CD 437 include:
Brigger et al (2015) Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. J Neurosci 6 e1861 PMID: 26313912
Huang et al (2019) Perturbational Gene-Expression Signatures for Combinatorial Drug Discovery. iScience 15 291 PMID: 31102995
Lee et al (2017) Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell 21 179 PMID: 28777944
Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 e0178116 PMID: 28552962
Do you know of a great paper that uses CD 437 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.