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Submit ReviewCeranib 1
Description: Ceramidase inhibitor; antiproliferative
Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Biological Activity for Ceranib 1
Ceranib 1 is a ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.
Technical Data for Ceranib 1
| M. Wt | 395.45 |
| Formula | C26H21NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 328076-61-5 |
| PubChem ID | 5761166 |
| InChI Key | OJMCCNQNCSCAJV-RVDMUPIBSA-N |
| Smiles | O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ceranib 1
References for Ceranib 1
References are publications that support the biological activity of the product.
Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864
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Keywords: Ceranib 1, Ceranib 1 supplier, Ceranib1, supplier, ceramidase, inhibitors, inhibits, antiproliferative, ceramides, accumulation, sphingosine, 1, phosphate, s1p, Ceramidases, 4448, Tocris Bioscience
1 Citation for Ceranib 1
Citations are publications that use Tocris products. Selected citations for Ceranib 1 include:
Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981
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