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Submit ReviewCGH 2466 dihydrochloride
Description: A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
Chemical Name: 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for CGH 2466 dihydrochloride
CGH 2466 dihydrochloride is an adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.
Technical Data for CGH 2466 dihydrochloride
| M. Wt | 395.13 |
| Formula | C14H9N3SCl2.2HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1177618-54-0 |
| PubChem ID | 16759176 |
| InChI Key | WHXRCTIBFLXKFD-UHFFFAOYSA-N |
| Smiles | Cl.Cl.NC1=NC(=C(S1)C1=CC=NC=C1)C1=CC(Cl)=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CGH 2466 dihydrochloride
References for CGH 2466 dihydrochloride
References are publications that support the biological activity of the product.
Trifilieff et al (2005) CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002 PMID: 15685201
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Keywords: CGH 2466 dihydrochloride, CGH 2466 dihydrochloride supplier, A1, A2B, A3, antagonists, inhibitors, inhibits, p38, MAPK, PDE4, Anti-inflammatory, agent, adenosines, receptor, Non-Selective, Receptors, Phosphodiesterases, CGH2466, dihydrochloride, Non-selective, Adenosine, 2344, Tocris Bioscience
1 Citation for CGH 2466 dihydrochloride
Citations are publications that use Tocris products. Selected citations for CGH 2466 dihydrochloride include:
Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661
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