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Submit ReviewCGP 42112
Description: Selective, high affinity AT2 ligand
Purity: ≥95% (HPLC)
Biological Activity for CGP 42112
CGP 42112 is a selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
Technical Data for CGP 42112
| M. Wt | 1052.2 |
| Formula | C52H69N13O11 |
| Sequence |
YKHPI (Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg)) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 127060-75-7 |
| PubChem ID | 123794 |
| InChI Key | UXGNARZDONUMMK-LRMQDCNJSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1=CN=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGP 42112
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for CGP 42112
References for CGP 42112
References are publications that support the biological activity of the product.
Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501
Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464
Criscione et al (1990) Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol. 16 S56
If you know of a relevant reference for CGP 42112, please let us know.
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Keywords: CGP 42112, CGP 42112 supplier, Selective, high, affinity, AT2, ligands, Receptors, Angiotensin, CGP42112, 2569, Tocris Bioscience
3 Citations for CGP 42112
Citations are publications that use Tocris products. Selected citations for CGP 42112 include:
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088
Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291 PMID: 22911895
Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483 PMID: 22738920
Do you know of a great paper that uses CGP 42112 from Tocris? Please let us know.
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