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Submit ReviewCHDI 00390576
Description: Potent and selective class IIa HDAC inhibitor; brain penetrant
Chemical Name: 2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide
Purity: ≥98% (HPLC)
Biological Activity for CHDI 00390576
CHDI 00390576 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor (IC50 values are 31, 50, 54 and 60 nM for HDAC7, HDAC9, HDAC4 and HDAC5, respectively). Displays >100-fold selectivity for class IIa HDACs over other HDACs. Brain penetrant.
Licensing Information
Sold under license from CHDI Foundation
Technical Data for CHDI 00390576
| M. Wt | 391.32 |
| Formula | C19H13F4N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1629729-98-1 |
| PubChem ID | 81689842 |
| InChI Key | LMGDHGQJJLEAPQ-UHFFFAOYSA-N |
| Smiles | ONC(C(C1=C(C=CC=C1)F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHDI 00390576
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.13 | 100 | |
| ethanol | 39.13 | 100 |
Preparing Stock Solutions for CHDI 00390576
The following data is based on the product molecular weight 391.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.78 mL | 25.55 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets for CHDI 00390576
References for CHDI 00390576
References are publications that support the biological activity of the product.
Luckhurst et al (2019) Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg.Med.Chem.Lett. 29 83 PMID: 30463802
If you know of a relevant reference for CHDI 00390576, please let us know.
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Citations for CHDI 00390576
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