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Submit ReviewCHDI 00484077
Description: Potent and selective HDAC class IIa inhibitor
Chemical Name: N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for CHDI 00484077
CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC50 values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.
Licensing Information
Sold under license from CHDI Foundation
Technical Data for CHDI 00484077
| M. Wt | 382.39 |
| Formula | C18H21F3N4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 3025894-92-9 |
| PubChem ID | 162675553 |
| InChI Key | DBWSFWPXCPNWRZ-NEPJUHHUSA-N |
| Smiles | O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)N[C@@H](CN3[C@H](CCC3)C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHDI 00484077
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.24 | 100 with gentle warming | |
| ethanol | 38.24 | 100 with gentle warming |
Preparing Stock Solutions for CHDI 00484077
The following data is based on the product molecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.08 mL | 26.15 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for CHDI 00484077
References for CHDI 00484077
References are publications that support the biological activity of the product.
Stott et al (2021) Evaluation of 5-(trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease. ACS Med.Chem.Lett 12 380 PMID: 33738065
If you know of a relevant reference for CHDI 00484077, please let us know.
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Keywords: CHDI 00484077, CHDI 00484077 supplier, CHDI00484077, potent, selective, inhibitors, inhibits, histone, deacetylase, class, II, IIa, HDAC4, epigenetics, Huntington, Class, HDACs, 7879, Tocris Bioscience
Citations for CHDI 00484077
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