Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewChlorpromazine hydrochloride
Description: Antipsychotic; D2 and H1 antagonist
Alternative Names: CPZ
Chemical Name: 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Chlorpromazine hydrochloride
Dopamine receptor antagonist; reduces neurotransmitter binding. Inhibits nitric oxide synthesis in mouse brain cytosol. Also an antagonist of nAChR, histamine and 5-HT receptors. Displays growth-inhibitory effects on numerous tumor cell lines. Exhibits antipsychotic activity.
Technical Data for Chlorpromazine hydrochloride
| M. Wt | 355.33 |
| Formula | C17H19ClN2S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 69-09-0 |
| Smiles | ClC3=CC2=C(C=C3)SC1=CC=CC=C1N2CCCN(C)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Chlorpromazine hydrochloride
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Please contact Customer Service
References for Chlorpromazine hydrochloride
References are publications that support the biological activity of the product.
Martinez and Coleman (1990) A comparison of the effects of chlorprom. and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int.J.Immunopharmacol. 12 185 PMID: 2329012
Eisenberg et al (2008) Differential interference of chlorprom. with the membrane interactions of oncogenic K-ras and its effects on cell growth. J.Biol.Chem. 283 27279 PMID: 18693247
Chiara et al (2009) [3H]chlorpromazine photolabeling of the Torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry 48 10066 PMID: 19754159
Palacios et al (1993) Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge. Biochem.Biophys.Res.Comms. 196 280
Cohen et al (1997) Characterization of the discriminative stimulus produced by the DA antagonist tiapride. J.Pharm.Exp.Ther. 283 573
View Related Products by Target
Keywords: Chlorpromazine hydrochloride, Chlorpromazine hydrochloride supplier, Chlorpromazine, HCl, dopamine, D2, receptor, antagonist, histamine, H1, antagonists, CPZ, Miscellaneous, Compounds, 4097, Tocris Bioscience
Citations for Chlorpromazine hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Chlorpromazine hydrochloride.
Reviews for Chlorpromazine hydrochloride
There are currently no reviews for this product. Be the first to review Chlorpromazine hydrochloride and earn rewards!
Have you used Chlorpromazine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image