Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCHPG Sodium salt
Description: Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
Purity: ≥99% (HPLC)
Biological Activity for CHPG Sodium salt
CHPG Sodium salt is a sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).
Compound Libraries for CHPG Sodium salt
CHPG Sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CHPG Sodium salt
| M. Wt | 223.59 |
| Formula | C8H7ClNNaO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1303993-73-8 |
| PubChem ID | 52974246 |
| InChI Key | KZRZZIISUUINJT-UHFFFAOYSA-M |
| Smiles | [Na+].NC(C([O-])=O)C1=CC(O)=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHPG Sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.18 | 50 | |
| DMSO | 11.18 | 50 |
Preparing Stock Solutions for CHPG Sodium salt
The following data is based on the product molecular weight 223.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.94 mL | 44.72 mL | 89.45 mL |
| 2.5 mM | 1.79 mL | 8.94 mL | 17.89 mL |
| 5 mM | 0.89 mL | 4.47 mL | 8.94 mL |
| 25 mM | 0.18 mL | 0.89 mL | 1.79 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for CHPG Sodium salt
References for CHPG Sodium salt
References are publications that support the biological activity of the product.
Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265 PMID: 9144665
Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057 PMID: 10455248
Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173 PMID: 11743947
If you know of a relevant reference for CHPG Sodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CHPG Sodium salt, CHPG Sodium salt supplier, mGlu5, mGluR5, selective, agonist, mGlur, Group, I, Receptors, Glutamate, Metabotropic, (Metabotropic), 3695, Tocris Bioscience
2 Citations for CHPG Sodium salt
Citations are publications that use Tocris products. Selected citations for CHPG Sodium salt include:
Hyuk Soo et al (2021) Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 74 2170-2185 PMID: 33932306
Yangyang et al (2021) CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5. Glia 69 1950-1965 PMID: 33811383
Do you know of a great paper that uses CHPG Sodium salt from Tocris? Please let us know.
Reviews for CHPG Sodium salt
There are currently no reviews for this product. Be the first to review CHPG Sodium salt and earn rewards!
Have you used CHPG Sodium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.