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Submit ReviewCI 1020
Description: Highly selective, orally active ETA antagonist
Alternative Names: PD 156707
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
Purity: ≥98% (HPLC)
Biological Activity for CI 1020
CI 1020 is a highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for CI 1020
| M. Wt | 506.5 |
| Formula | C28H26O9 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 162256-50-0 |
| PubChem ID | 9870830 |
| InChI Key | PWIPORDFWDZCJG-UHFFFAOYSA-N |
| Smiles | O=C1C(C2=CC=C(OCO4)C4=C2)=C(CC3=CC(OC)=C(OC)C(OC)=C3)C(O)(C5=CC=C(OC)C=C5)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CI 1020
References for CI 1020
References are publications that support the biological activity of the product.
Doherty et al (1995) Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. J.Med.Chem. 38 1259 PMID: 7731010
Jones et al (1999) The effect of the endothelin ETA receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur.J.Pharmacol. 374 367 PMID: 10422781
Coe et al (2002) The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in ther perinatal lamb. J.Pharmacol.Exp.Ther. 302 672 PMID: 12130731
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Keywords: CI 1020, CI 1020 supplier, selective, orally, active, ETA, antagonists, Receptors, Endothelin, CI1020, Pfizer, PD156707, PD, 156707, 2942, Tocris Bioscience
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