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Description: Caged inositol triphosphate
Chemical Name: 6-O-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-2,3-O-(1-methylethylidene)-D-myo-Inositol 1,4,5-tris[bis[(1-oxopropoxy)methyl]phosphate]
Purity: ≥98% (HPLC)
Biological Activity for ci-IP3/PM
ci-IP3/PM is a caged inositol triphosphate. Cell permeable. UV photolysis (λ = 330 nm) in HeLa cells releases i-IP3, promoting Ca2+-release from internal stores.
F 127 (Cat. No. 6253) for the solubilization of ci-IP3/PM is also available.
Technical Data for ci-IP3/PM
| M. Wt | 1171.87 |
| Formula | C42H64NO31P3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1009832-82-9 |
| PubChem ID | 124221754 |
| InChI Key | FNWIHZJMPHUCAI-RJQNPCEJSA-N |
| Smiles | CC(O1)(C)O[C@H]([C@H]1[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OCC3=CC(OC)=C(OC)C=C3[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ci-IP3/PM
| Solubility | Soluble in DMSO |
Product Datasheets for ci-IP3/PM
References for ci-IP3/PM
References are publications that support the biological activity of the product.
Dakin and Li et al (2007) Cell membrane permeable esters of D-myo-inositol 1,4,5-trisphosphate. Cell Calcium 42 291 PMID: 17307252
Lock et al (2017) Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium PMID: 28108028
Zhang et al (2004) Endothelin-1 and IP3 induced Ca2+ sparks in pulmonary arterial smooth muscle cells. J.Cardiovasc.Pharmacol. 44 S121 PMID: 15838259
If you know of a relevant reference for ci-IP3/PM, please let us know.
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Keywords: ci-IP3/PM, ci-IP3/PM supplier, Caged, IP3, activated, intracellular, Ca2+, calcium, stores, photolysis, UV, inositol, triphosphate, Second, Messenger, Compounds, Receptors, 6210, Tocris Bioscience
9 Citations for ci-IP3/PM
Citations are publications that use Tocris products. Selected citations for ci-IP3/PM include:
Vinu et al (2020) Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells. Sci Signal 13 PMID: 32071168
Sundeep et al (2021) CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors. J Cell Sci 134 PMID: 34533188
David I et al (2021) Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep 34 108760 PMID: 33657364
David I et al (2021) A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy. STAR Protoc 2 100618 PMID: 34195673
David I et al (2021) The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. J Biol Chem 297 101174 PMID: 34499925
Jonathan et al (2023) Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging. CNS Neurosci Ther 29 365-377 PMID: 36419337
Tiziano et al (2023) Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2 pgac288 PMID: 36712939
Sundeep et al (2022) Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A 119 e2209267119 PMID: 36122240
Yu et al (2022) Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. Nat Commun 13 4481 PMID: 35918320
Do you know of a great paper that uses ci-IP3/PM from Tocris? Please let us know.
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