Home / Pharmacology / Nuclear Receptors / Other Nuclear Receptors / Other Nuclear Receptor Inhibitors / CIA 1

CIA 1

Cat. No. 7494 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: COUP-TFII inhibitor
Chemical Name: N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CIA 1

CIA 1 is an inhibitor of the nuclear receptor COUP-TFII (IC50 ranged from 1.2 μM to 7.6 μM, in prostate cancer cell lines). In vitro, CIA 1 inhibits growth of multiple prostate cancer cell lines and suppresses COUP-TFII activity to regulate its target genes. In vivo, CIA 1 reduces tumor growth in prostate cancer xenograft mouse models.

Technical Data for CIA 1

M. Wt 365.88
Formula C17H19N3O2S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1049691-47-5
PubChem ID 2974648
InChI Key PYRMFONFWQTEGD-UHFFFAOYSA-N
Smiles COC1=C(C=C(C=C1)CCNC2=C3C=C(SC3=NC=N2)C)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CIA 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.32 20

Preparing Stock Solutions for CIA 1

The following data is based on the product molecular weight 365.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.67 mL 68.33 mL 136.66 mL
1 mM 2.73 mL 13.67 mL 27.33 mL
2 mM 1.37 mL 6.83 mL 13.67 mL
10 mM 0.27 mL 1.37 mL 2.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for CIA 1

References are publications that support the biological activity of the product.

Wang et al (2020) Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci.Adv. 6 eaaz8031 PMID: 32494682

If you know of a relevant reference for CIA 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Nuclear Receptor Inhibitors

Keywords: CIA 1, CIA 1 supplier, inhibitors, inhibits, COUP, TFII, nuclear, receptor, prostate, cancer, NR2F2, TFCOUP2, Other, Nuclear, Receptors, 7494, Tocris Bioscience

Citations for CIA 1

Citations are publications that use Tocris products.

Currently there are no citations for CIA 1. Do you know of a great paper that uses CIA 1 from Tocris? Please let us know.

Reviews for CIA 1

There are currently no reviews for this product. Be the first to review CIA 1 and earn rewards!

Have you used CIA 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review