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Submit ReviewCilnidipine
Description: Dual CaV1.x and CaV2.x blocker
Alternative Names: FRC 8653
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
Purity: ≥99% (HPLC)
Biological Activity for Cilnidipine
Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
Compound Libraries for Cilnidipine
Cilnidipine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Cilnidipine
| M. Wt | 492.52 |
| Formula | C27H28N2O7 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 132203-70-4 |
| PubChem ID | 2752 |
| InChI Key | KJEBULYHNRNJTE-UHFFFAOYSA-N |
| Smiles | COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cilnidipine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.25 | 100 | |
| ethanol | 4.92 | 10 |
Preparing Stock Solutions for Cilnidipine
The following data is based on the product molecular weight 492.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.15 mL | 20.3 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets for Cilnidipine
References for Cilnidipine
References are publications that support the biological activity of the product.
Murai et al (2000) Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 854 6 PMID: 10784100
Takahara et al (2004) Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model. Biol.Pharm.Bull. 27 1388 PMID: 15340224
Nap et al (2004) The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. Fund.Clin.Pharmacol. 18 309
If you know of a relevant reference for Cilnidipine, please let us know.
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Keywords: Cilnidipine, Cilnidipine supplier, Ca2+, channel, blockers, dual, L/N-type, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, FRC8653, FRC, 8653, Cav1.x, Cav2.x, 2629, Tocris Bioscience
Citations for Cilnidipine
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Currently there are no citations for Cilnidipine. Do you know of a great paper that uses Cilnidipine from Tocris? Please let us know.
Reviews for Cilnidipine
Average Rating: 4 (Based on 1 Review.)
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The effect of Cilnidipine was studied on the N-type Ca2+ channel.
By
Anonymous on 02/12/2019
Species: Human
The effect of Cilnidipine was studied on the N-type Ca2+ channel. Due to its blocking action at the N-type and L-type calcium channel, cilnidipine dilates both arterioles and venules, reducing the pressure in the capillary bed.
