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Submit ReviewCinnabarinic acid
Discontinued Product
4119 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Selective mGlu4 agonist
Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for Cinnabarinic acid
Cinnabarinic acid is a mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
Technical Data for Cinnabarinic acid
| M. Wt | 300.22 |
| Formula | C14H8N2O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 606-59-7 |
| PubChem ID | 114918 |
| InChI Key | FSBKJYLVDRVPTK-UHFFFAOYSA-N |
| Smiles | O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cinnabarinic acid
References for Cinnabarinic acid
References are publications that support the biological activity of the product.
Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print PMID: 22311707
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Keywords: Cinnabarinic acid, Cinnabarinic acid supplier, metabotropic, glutamate, mglu4, agonists, selective, Glutamate, (Metabotropic), Group, III, Receptors, 4119, Tocris Bioscience
Citations for Cinnabarinic acid
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Currently there are no citations for Cinnabarinic acid.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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