Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewcis-ACBD
Description: Potent, selective L-glutamate uptake inhibitor
Chemical Name: cis-1-Aminocyclobutane-1,3-dicarboxylic acid
Biological Activity for cis-ACBD
cis-ACBD is a potent, competitive and selective inhibitor of glutamate uptake. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboxylic acid and the amino groups on the same side of the cyclobutyl ring.
Technical Data for cis-ACBD
| M. Wt | 159.14 |
| Formula | C6H9NO4 |
| Storage | Store at RT |
| CAS Number | 73550-55-7 |
| PubChem ID | 1214 |
| InChI Key | GGMYWPBNZXRMME-UHFFFAOYSA-N |
| Smiles | [H][C@@]1([C@@](O)=O)C[C@@](N)([C@](O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for cis-ACBD
References for cis-ACBD
References are publications that support the biological activity of the product.
Allan et al (1990) Synthesis and activity of a potent NMDA agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. J.Med.Chem. 33 2905 PMID: 2145435
Fletcher et al (1991) Inhibition of L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid. Neurosci.Lett. 121 133 PMID: 1673544
Koch et al (1999) Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters. Mol.Pharmacol. 56 1095 PMID: 10570036
View Related Products by Target
View Related Products by Product Action
Keywords: cis-ACBD, cis-ACBD supplier, Potent, selective, competitive, L-glutamate, uptake, inhibitors, inhibits, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0271, Tocris Bioscience
1 Citation for cis-ACBD
Citations are publications that use Tocris products. Selected citations for cis-ACBD include:
Lee et al (2010) Characterisation of the expression of NMDA receptors in human astrocytes. PLoS One 5 e14123 PMID: 21152063
Reviews for cis-ACBD
There are currently no reviews for this product. Be the first to review cis-ACBD and earn rewards!
Have you used cis-ACBD?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.