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Submit Reviewcis VH 032, amine dihydrochloride
Description: Negative control for VH 032, amine (Cat. No. 6462)
Alternative Names: (S,S,S)-AHPC
Chemical Name: (2S,4S)-1-[(2S)-2-Amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for cis VH 032, amine dihydrochloride
cis VH 032, amine dihydrochloride is a negative control for the functionalized VHL ligand VH 032, amine (Cat. No. 6462).
Usage Guidelines for cis VH 032, amine dihydrochloride
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for cis VH 032, amine dihydrochloride
| M. Wt | 503.48 |
| Formula | C22H30N4O3S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2376990-32-6 |
| Smiles | CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for cis VH 032, amine dihydrochloride
References for cis VH 032, amine dihydrochloride
References are publications that support the biological activity of the product.
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Keywords: cis VH 032, amine dihydrochloride, cis VH 032, amine dihydrochloride supplier, VH032, amine, 2HCl, protein, degrader, 1, VHL, VL, 269, PROTACs, E3, ligase, ligands, negative, control, 2115897-23-7, 1797406-78-0, (S,S,S)-AHPC, Functionalized, Ligase, Ligands, 6969, Tocris Bioscience
1 Citation for cis VH 032, amine dihydrochloride
Citations are publications that use Tocris products. Selected citations for cis VH 032, amine dihydrochloride include:
Smalley et al (2020) PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes. Chem.Commun.(Camb) 56 4476 PMID: 32201871
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Literature in this Area
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia