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Submit ReviewCitalopram hydrobromide
Description: Highly potent and selective 5-HT uptake inhibitor
Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Purity: ≥99% (HPLC)
Biological Activity for Citalopram hydrobromide
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.
Technical Data for Citalopram hydrobromide
| M. Wt | 405.31 |
| Formula | C20H21FN2O.HBr |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 59729-32-7 |
| PubChem ID | 77995 |
| InChI Key | WIHMBLDNRMIGDW-UHFFFAOYSA-N |
| Smiles | Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Citalopram hydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 50 | ||
| water | 10 |
Preparing Stock Solutions for Citalopram hydrobromide
The following data is based on the product molecular weight 405.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.93 mL | 24.67 mL | 49.34 mL |
| 2.5 mM | 0.99 mL | 4.93 mL | 9.87 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
| 25 mM | 0.1 mL | 0.49 mL | 0.99 mL |
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Product Datasheets for Citalopram hydrobromide
References for Citalopram hydrobromide
References are publications that support the biological activity of the product.
Auerbach and Hjorth (1995) Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor cital. on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch.Pharmacol. 352 597 PMID: 9053730
Mateo et al (2000) Inhibition of 5-hydroxytryptamine reuptake by the antidepressant cital. in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 39 2036 PMID: 10963747
Hyttel (1982) Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Drug Metabolism. Eds. Bridges, J. W. & Ch 6 277
If you know of a relevant reference for Citalopram hydrobromide, please let us know.
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Keywords: Citalopram hydrobromide, Citalopram hydrobromide supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1427, Tocris Bioscience
14 Citations for Citalopram hydrobromide
Citations are publications that use Tocris products. Selected citations for Citalopram hydrobromide include:
Jury et al (2015) Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation. PLoS One 10 e0117339 PMID: 25689282
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
Munari et al (2015) Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Psychopharmacology (Berl) 18 pyv045 PMID: 25899065
Phelps et al (2015) Psychopharmacological characterisation of the successive negative contrast effect in rats. Mol Ther 232 2697 PMID: 25791190
Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748
Jiménez-Sánchez et al (2014) The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression. Neuropsychopharmacology 39 2673 PMID: 24871546
Morecroft et al (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Int J Neuropsychopharmacol 85 593 PMID: 19736308
Gasull-Camôs et al (2018) Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex. Neuropharmacology 139 41 PMID: 29940206
Morecroft et al (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. PLoS One 20 1516 PMID: 22525513
Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin. Cardiovasc Res 37 321 PMID: 21956448
Maciag et al (2006) Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31 47 PMID: 16012532
Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171 PMID: 17101120
Do you know of a great paper that uses Citalopram hydrobromide from Tocris? Please let us know.
Reviews for Citalopram hydrobromide
Average Rating: 5 (Based on 2 Reviews.)
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Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
Assay Type: In Vivo
Species: Mouse
SERT blocker citalopram (1 μΜ)
Citalopram with cued fear conditioning.
By
Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse
given before cued fear conditioning, 10mg/kg i.p. did not significantly affect freezing behavior during recall 24 hours later
dissolved in saline easily, given 60 min before behavior
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.