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Submit ReviewClemizole hydrochloride
Discontinued Product
This product has been withdrawn from sale and is superseded by AC 1903 (Cat. No. 6766)
Description: TRPC5 blocker; also H1 antagonist
Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Clemizole hydrochloride
TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.
Technical Data for Clemizole hydrochloride
| M. Wt | 362.3 |
| Formula | C19H20ClN3. HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1163-36-6 |
| PubChem ID | 14412 |
| InChI Key | DNFMJYXRIMLMBZ-UHFFFAOYSA-N |
| Smiles | ClC(C=C4)=CC=C4CN2C(CN3CCCC3)=NC1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Clemizole hydrochloride
References for Clemizole hydrochloride
References are publications that support the biological activity of the product.
Aguilar et al (1986) Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Br.J.Pharmacol. 88 501 PMID: 3742147
Richter et al (2014) Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol.Pharm. 86 514 PMID: 25140002
Baraban et al (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat.Commun. 4 2410 PMID: 24002024
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Keywords: Clemizole hydrochloride, Clemizole hydrochloride supplier, transient, potential, channels, TRPC5, histamine, receptors, blockers, antagonists, TRPC, Histamine, H1, Receptors, 5371, Tocris Bioscience
3 Citations for Clemizole hydrochloride
Citations are publications that use Tocris products. Selected citations for Clemizole hydrochloride include:
Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946
Fernandez-Fernandez et al (2018) Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS One 13 e0199282 PMID: 29928032
Ondrusova et al (2017) Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis. Sci Rep 7 16332 PMID: 29180820
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