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Submit ReviewClonidine hydrochloride
Description: α2 agonist. Also I1 ligand
Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Clonidine hydrochloride
Clonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
Technical Data for Clonidine hydrochloride
| M. Wt | 266.56 |
| Formula | C9H9Cl2N3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 4205-91-8 |
| PubChem ID | 20179 |
| InChI Key | ZNIFSRGNXRYGHF-UHFFFAOYSA-N |
| Smiles | Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Clonidine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.66 | 100 | |
| DMSO | 13.33 | 50 |
Preparing Stock Solutions for Clonidine hydrochloride
The following data is based on the product molecular weight 266.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.76 mL | 37.52 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.5 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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Product Datasheets for Clonidine hydrochloride
References for Clonidine hydrochloride
References are publications that support the biological activity of the product.
Armitsu et al (1998) Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681 PMID: 9694921
Ernsberger et al (1987) clon. binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1 PMID: 3030779
Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1 PMID: 7883019
Silva et al (1996) Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872 PMID: 8627569
Merck Index 12 2450
Williams et al (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 4 295 PMID: 18391949
If you know of a relevant reference for Clonidine hydrochloride, please let us know.
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Keywords: Clonidine hydrochloride, Clonidine hydrochloride supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, agonists, I1, ligand, Receptors, Imidazoline, Adrenergic, Alpha-2, Autophagy, 0690, Tocris Bioscience
9 Citations for Clonidine hydrochloride
Citations are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:
Cinelli et al (2013) Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep 1 e00122 PMID: 24400133
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain 5 11 PMID: 19284549
Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560
Devoto et al (2015) Selective inhibition of DA-β-hydroxylase enhances DA release from noradrenergic terminals in the medial prefrontal cortex. Mol Pain 5 e00393 PMID: 26516613
Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Purinergic Signal 7 4 PMID: 21219650
Liu et al (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett 493 72 PMID: 21241772
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
Do you know of a great paper that uses Clonidine hydrochloride from Tocris? Please let us know.
Reviews for Clonidine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Behavioral pharmacology studies in rodents.
By
Anonymous on 01/04/2018
Assay Type: In Vivo
Species: Rat
Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.
High doses (great than 1 mg/kg) results in self-injurious behavior in rats.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.