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Clotrimazole

Cat. No. 4096 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Cytochrome P450 inhibitor; antifungal
Alternative Names: CLT
Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Clotrimazole

Clotrimazole is an imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).

Compound Libraries for Clotrimazole

Clotrimazole is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Clotrimazole

M. Wt 344.84
Formula C22H17ClN2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 23593-75-1
PubChem ID 2812
InChI Key VNFPBHJOKIVQEB-UHFFFAOYSA-N
Smiles ClC1=CC=CC=C1C(C3=CC=CC=C3)(C4=CC=CC=C4)N2C=CN=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Clotrimazole

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.86 75
ethanol 34.48 100

Preparing Stock Solutions for Clotrimazole

The following data is based on the product molecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.5 mL 29 mL
5 mM 0.58 mL 2.9 mL 5.8 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Clotrimazole

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Clotrimazole

References are publications that support the biological activity of the product.

Snajdrova et al (1998) Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 273 28032 PMID: 9774419

Wu et al (1999) Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38 979 PMID: 10428416

Thomas et al (1999) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 126 1531 PMID: 10323582

Lempiainen et al (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 19 2258 PMID: 15905360

If you know of a relevant reference for Clotrimazole, please let us know.

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Keywords: Clotrimazole, Clotrimazole supplier, inhibits, calcium-activated, potassium, channels, Ca2+-activated, K+, inhibitors, antifungal, antimycotic, cytochrome, P450, oxidase, CLT, Cytochrome, Constitutive, Androstane, Receptor, Antifungals, 4096, Tocris Bioscience

3 Citations for Clotrimazole

Citations are publications that use Tocris products. Selected citations for Clotrimazole include:

Rossen et al (2021) Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection. PLoS Pathog 17 e1009557 PMID: 33956874

Anne-Amandine et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705

Mark M et al (2021) Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition. Elife 10 PMID: 33856345

Do you know of a great paper that uses Clotrimazole from Tocris? Please let us know.

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