Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCM 10
Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells
Chemical Name: 2-(2-Propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]phenol
Purity: ≥98% (HPLC)
Biological Activity for CM 10
CM 10 is a aldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC50 values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133+ ovarian cancer stem cells in vitro.
Technical Data for CM 10
| M. Wt | 321.42 |
| Formula | C20H23N3O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 692269-09-3 |
| PubChem ID | 889692 |
| InChI Key | ZFHWEWJDCFGRBO-UHFFFAOYSA-N |
| Smiles | CCCN1C(NCC2=C(O)C(CC=C)=CC=C2)=NC2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CM 10
References for CM 10
References are publications that support the biological activity of the product.
Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894
Morgan & Hurley (2015) Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem.Biol.Interact. 234 29 PMID: 25450233
View Related Products by Target
View Related Products by Product Action
Keywords: CM 10, CM 10 supplier, CM10, aldehyde, dehydrogenase, inhibitors, inhibits, ALDH1A, cancer, stem, cells, Aldehyde, Dehydrogenase, Cancer, Stem, Cells, 6933, Tocris Bioscience
Citations for CM 10
Citations are publications that use Tocris products.
Currently there are no citations for CM 10.
Reviews for CM 10
There are currently no reviews for this product. Be the first to review CM 10 and earn rewards!
Have you used CM 10?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image