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CMA

Cat. No. 6677 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Murine-selective STING agonist
Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CMA

CMA is a STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.

Compound Libraries for CMA

CMA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CMA

M. Wt 253.25
Formula C15H11NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 38609-97-1
PubChem ID 38072
InChI Key UOMKBIIXHQIERR-UHFFFAOYSA-N
Smiles OC(CN1C2=CC=CC=C2C(C3=C1C=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CMA

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.32 100

Preparing Stock Solutions for CMA

The following data is based on the product molecular weight 253.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.49 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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References for CMA

References are publications that support the biological activity of the product.

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723

Cavlar et al (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32 1440 PMID: 23604073

Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci. Rep. 5 18035 PMID: 26669264

If you know of a relevant reference for CMA, please let us know.

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Keywords: CMA, CMA supplier, Murine-selective, STING, agonists, agonism, STING-Dependent, Signaling, 6677, Tocris Bioscience

1 Citation for CMA

Citations are publications that use Tocris products. Selected citations for CMA include:

Jie et al (2023) Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome. iScience 26 106758 PMID: 37216118

Do you know of a great paper that uses CMA from Tocris? Please let us know.

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