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Description: Potent and selective non-NMDA iGluR antagonist
Alternative Names: Cyanquixaline
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione
Purity: ≥99% (HPLC)
Biological Activity for CNQX
CNQX is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor-mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.
CNQX Disodium Salt (Cat. No. 1045) also available.
Compound Libraries for CNQX
CNQX is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CNQX
| M. Wt | 232.16 |
| Formula | C9H4N4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115066-14-3 |
| PubChem ID | 3721046 |
| InChI Key | RPXVIAFEQBNEAX-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=C(C=C2NC(=O)C(=O)NC2=C1)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CNQX
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.22 | 100 |
Preparing Stock Solutions for CNQX
The following data is based on the product molecular weight 232.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.31 mL | 21.54 mL | 43.07 mL |
| 5 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets for CNQX
References for CNQX
References are publications that support the biological activity of the product.
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909
King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375 PMID: 1358390
Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850 PMID: 1976402
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495
If you know of a relevant reference for CNQX, please let us know.
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Keywords: CNQX, CNQX supplier, Potent, AMPA/kainate, antagonists, antagonism, NMDA, glycine, site, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, N-Methyl-D-Aspartate, neuroprotective, Cyanquixaline, 0190, Tocris Bioscience
214 Citations for CNQX
Citations are publications that use Tocris products. Selected citations for CNQX include:
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CNQX impact on field potentials PPR.
By
Anonymous on 06/07/2019
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Anterior singulate cortex
CNQX was used to study input of non-NMDA glutamate receptors into short-term plasticity in anterior cingulate cortex. Being applied in 5 microM concentration, CNQX reduced significantly both amplitudes of field potentials and their paired-pulse ratio.
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