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Submit ReviewConantokin-T
Description: Non-competitive NMDA antagonist
Biological Activity for Conantokin-T
Non-competitive NMDA receptor antagonist (IC50 = 0.4 μM). Inhibits Ca2+ influx and glutamate-induced toxicity in central nervous system neurons. Exhibits age-dependent physiological effects; induces a sleep-like state in young mice and hyperactivity in older mice.
Licensing Information
Sold under license from University of Utah
Technical Data for Conantokin-T
| M. Wt | 2683.8 |
| Formula | C110H175N31O45S |
| Sequence |
GEXXYQKMLXNLRXAEVKKNA (Modifications: X = Gla, Ala-21 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 127476-26-0 |
| PubChem ID | 16143008 |
| InChI Key | UFVIUSQQHPISRQ-HNJXWIPGSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Conantokin-T
References for Conantokin-T
References are publications that support the biological activity of the product.
Haack et al (1990) Conantokin-T. J.Biol.Chem. 265 6025 PMID: 2180939
Klein et al (1999) Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology 38 1819 PMID: 10608277
Warder et al (2001) Amino acid determinants for NMDA receptor inhibition by conantokin-T. J.Neurochem. 77 812 PMID: 11331410
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Keywords: Conantokin-T, Conantokin-T supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, venoms, 3122, Tocris Bioscience
Citations for Conantokin-T
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Currently there are no citations for Conantokin-T.
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