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Discontinued Product
2409 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Potent and selective H3 receptor antagonist
Chemical Name: N,N-Dimethyl-con-5-enin-3-amine
Biological Activity for Conessine
Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).
Technical Data for Conessine
| M. Wt | 356.59 |
| Formula | C24H40N2 |
| Storage | Store at RT |
| CAS Number | 546-06-5 |
| PubChem ID | 441082 |
| InChI Key | GPLGAQQQNWMVMM-MYAJQUOBSA-N |
| Smiles | [H][C@@]23CC=C1C[C@@H](N(C)C)CC[C@@](C)1[C@]([H])2CC[C@@]45[C@]([H])3CC[C@@]([H])4[C@H](C)N(C)C5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Conessine
References for Conessine
References are publications that support the biological activity of the product.
Zirihi et al (2005) Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg.Med.Chem.Lett. 15 2637 PMID: 15863333
Zhao et al (2008) The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J.Med.Chem. 51 5423 PMID: 18683917
Witte et al (2005) Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist. Soc.Neurosci.Abstr. 491 19
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Keywords: Conessine, Conessine supplier, Potent, selective, H3, receptor, antagonists, Receptors, Histamine, histaminergic, 2409, Tocris Bioscience
Citations for Conessine
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Currently there are no citations for Conessine.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.