Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCP 93129 dihydrochloride
Description: 5-HT1B agonist
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Biological Activity for CP 93129 dihydrochloride
CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for CP 93129 dihydrochloride
| M. Wt | 288.18 |
| Formula | C12H13N3O.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 879089-64-2 |
| PubChem ID | 46927988 |
| InChI Key | FLVJHUZZKVJQNH-UHFFFAOYSA-N |
| Smiles | Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CP 93129 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.82 | 100 | |
| water | 28.82 | 100 |
Preparing Stock Solutions for CP 93129 dihydrochloride
The following data is based on the product molecular weight 288.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.35 mL | 34.7 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for CP 93129 dihydrochloride
References for CP 93129 dihydrochloride
References are publications that support the biological activity of the product.
Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817
Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241
Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 24381287
If you know of a relevant reference for CP 93129 dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CP 93129 dihydrochloride, CP 93129 dihydrochloride supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 1032, Tocris Bioscience
9 Citations for CP 93129 dihydrochloride
Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:
Medrihan et al (2017) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron 95 564 PMID: 28735749
Zhou et al (2019) Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation. Behav Brain Res 356 148 PMID: 29949735
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552
Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther 51 239 PMID: 16846858
Rau et al (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med 318 676 PMID: 16687477
Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517
Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045
Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron 19 1915 PMID: 19056862
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex 3 e00103 PMID: 25692021
Do you know of a great paper that uses CP 93129 dihydrochloride from Tocris? Please let us know.
Reviews for CP 93129 dihydrochloride
Average Rating: 3.7 (Based on 3 Reviews.)
Have you used CP 93129 dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Modulation of spontaneous interneuronal signalling.
By
Sergiy Sylantyev on 12/10/2023
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Arcuate nucleus
CP 93129 was used to modulate spontaneous generation of action potentials in neurons of arcuate nucleus. Illustration: application of 100 nM CP 93129 (grey bar) decreases frequency of AP generation in living neuron.
5-HT has a potential for relaxant.
By
Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat
CP93129 (5-HT1B)10nM
Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By
Anonymous on 02/03/2020
Assay Type: In Vivo
Species: Mouse
CP (10mM)
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.