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Submit ReviewCPYPP
Description: DOCK2-Rac1 interaction inhibitor
Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Purity: ≥98% (HPLC)
Biological Activity for CPYPP
CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.
Technical Data for CPYPP
| M. Wt | 324.76 |
| Formula | C18H13ClN2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 310460-39-0 |
| PubChem ID | 2248187 |
| InChI Key | VVZJFICTTKPNCK-XWDZFIQBSA-N |
| Smiles | O=C(N(C3=CC=CC=C3)NC2=O)/C2=C\C=C\C1=C(Cl)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CPYPP
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.5 | 20 |
Preparing Stock Solutions for CPYPP
The following data is based on the product molecular weight 324.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.4 mL | 76.98 mL | 153.96 mL |
| 1 mM | 3.08 mL | 15.4 mL | 30.79 mL |
| 2 mM | 1.54 mL | 7.7 mL | 15.4 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
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Product Datasheets for CPYPP
References for CPYPP
References are publications that support the biological activity of the product.
Nishikimi et al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488 PMID: 22520755
Laurin et al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434 PMID: 23592719
If you know of a relevant reference for CPYPP, please let us know.
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Keywords: CPYPP, CPYPP supplier, DOCK2, DOCK1, DOCK180, DOCK5, Rac1, interaction, inhibitors, inhibits, Rho, 4568, Tocris Bioscience
1 Citation for CPYPP
Citations are publications that use Tocris products. Selected citations for CPYPP include:
Sayan et al (2019) MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia. FASEB J 33 5268-5286 PMID: 30668141
Do you know of a great paper that uses CPYPP from Tocris? Please let us know.
Reviews for CPYPP
Average Rating: 4 (Based on 1 Review.)
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Inhibits cell migration.
By
Kishor Pant on 03/24/2023
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HepG2, and Huh
CPYPP inhibited cell migration in HCC in vitro. Image: top panel shows result at 0 h; bottom panel at 48 h.
