CU CPT 9a

Cat. No. 6479 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Highly potent TLR8 inhibitor

Chemical Name: 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CU CPT 9a

CU CPT 9a is a potent TLR8 inhibitor (IC₅₀ = 0.5 nM and K_d = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries for CU CPT 9a

CU CPT 9a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CU CPT 9a

M. Wt	265.31
Formula	C₁₇H₁₅NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2165340-32-7
PubChem ID	135567383
InChI Key	HNYBTVKYLVLWCB-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C(C3=CC(C)=C(C=C3)O)=CC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CU CPT 9a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.53	100
	ethanol	5.31	20

Preparing Stock Solutions for CU CPT 9a

The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.85 mL	37.69 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.88 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for CU CPT 9a

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for CU CPT 9a

References are publications that support the biological activity of the product.

Zhang et al (2018) Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 14 58 PMID: 29155428

If you know of a relevant reference for CU CPT 9a, please let us know.

View Related Products by Target

Toll-like Receptors

View Related Products by Product Action

View all Toll-like Receptor Inhibitors

Keywords: CU CPT 9a, CU CPT 9a supplier, CUCPT9a, toll-like, receptors, TLR8, inhibitors,, inhibits, potent, Toll-like, Receptors, 6479, Tocris Bioscience

Citations for CU CPT 9a

Citations are publications that use Tocris products.

Currently there are no citations for CU CPT 9a. Do you know of a great paper that uses CU CPT 9a from Tocris? Please let us know.

Reviews for CU CPT 9a

There are currently no reviews for this product. Be the first to review CU CPT 9a and earn rewards!

Have you used CU CPT 9a?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for CU CPT 9a

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.