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CVT 10216

Cat. No. 5164 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective ALDH2 inhibitor
Chemical Name: 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CVT 10216

CVT 10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.

Compound Libraries for CVT 10216

CVT 10216 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CVT 10216

M. Wt 465.48
Formula C24H19NO7S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1005334-57-5
PubChem ID 23661666
InChI Key YYOOFJZTRCPVFD-UHFFFAOYSA-N
Smiles O=C2C1=CC=C(OCC4=CC(C(O)=O)=CC=C4)C=C1OC=C2C3=CC=C(NS(=O)(C)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CVT 10216

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100
1eq. NaOH 23.27 50

Preparing Stock Solutions for CVT 10216

The following data is based on the product molecular weight 465.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References for CVT 10216

References are publications that support the biological activity of the product.

Overstreet et al (2009) A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 94 255 PMID: 19747934

Yao et al (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of DA synthesis. Nat.Med. 16 1024 PMID: 20729865

If you know of a relevant reference for CVT 10216, please let us know.

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Citations for CVT 10216

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