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Submit ReviewCX 546
Description: AMPA potentiator
Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Purity: ≥99% (HPLC)
Biological Activity for CX 546
CX 546 is an AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.
Technical Data for CX 546
| M. Wt | 247.29 |
| Formula | C14H17NO3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 215923-54-9 |
| PubChem ID | 2890 |
| InChI Key | LJUNPHMOGNFFOS-UHFFFAOYSA-N |
| Smiles | O=C(N3CCCCC3)C2=CC1=C(C=C2)OCCO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CX 546
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.73 | 100 | |
| ethanol | 24.73 | 100 |
Preparing Stock Solutions for CX 546
The following data is based on the product molecular weight 247.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets for CX 546
References for CX 546
References are publications that support the biological activity of the product.
Nagararjan et al (2001) Mechanism and impact of allosteric AMPA receptor modulation by the ampakine TM CX546. Neuropharmacology. 41 650 PMID: 11640919
O'Neill et al (2004) AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 3 181 PMID: 15180479
Shimazaki et al (2007) Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. Eur.J.Pharmacol. 575 94 PMID: 17727837
Huang et al (2016) Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci.Transl.Med. 8 ra85 PMID: 27334260
If you know of a relevant reference for CX 546, please let us know.
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Keywords: CX 546, CX 546 supplier, AMPA, receptor, potentiator, Glutamate, Receptors, iGluR, Ionotropic, CX546, 2980, Tocris Bioscience
Citations for CX 546
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