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Submit ReviewCX 614
Description: Positive allosteric modulator of AMPA receptors
Chemical Name: 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one
Purity: ≥99% (HPLC)
Biological Activity for CX 614
CX 614 is an AMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.
Compound Libraries for CX 614
CX 614 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CX 614
| M. Wt | 247.25 |
| Formula | C13H13NO4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 191744-13-5 |
| PubChem ID | 6451148 |
| InChI Key | RQEPVMAYUINZRE-UHFFFAOYSA-N |
| Smiles | O=C2N4C(CCC4)OC1=CC3=C(OCCO3)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CX 614
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.73 | 100 | |
| ethanol | 12.36 | 50 |
Preparing Stock Solutions for CX 614
The following data is based on the product molecular weight 247.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets for CX 614
References for CX 614
References are publications that support the biological activity of the product.
Harms et al (2013) Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology 64 45 PMID: 22735771
Timm et al (2011) Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 80 267 PMID: 21543522
Hennegriff et al (1997) Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators. J.Neurochem. 68 2424 PMID: 9166736
If you know of a relevant reference for CX 614, please let us know.
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Keywords: CX 614, CX 614 supplier, CX614, Positive, allosteric, modulators, AMPA, receptors, AMPAkines, benzamide, PAM, Receptors, 5149, Tocris Bioscience
3 Citations for CX 614
Citations are publications that use Tocris products. Selected citations for CX 614 include:
Susumu et al (2021) Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway. iScience 24 102504 PMID: 34113835
Carolina da Silveira et al (2021) Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish. Elife 10 PMID: 33720013
Ege T et al (2021) A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Cell Rep 36 109467 PMID: 34348149
Do you know of a great paper that uses CX 614 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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