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CY 09

Cat. No. 6436 Submit a Review Datasheet / COA / SDS
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Description: NLRP3 inhibitor; active in vivo
Chemical Name: 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CY 09

CY 09 is a NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).

Technical Data for CY 09

M. Wt 423.43
Formula C19H12F3NO3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1073612-91-5
PubChem ID 44561595
InChI Key DJTINRHPPGAPLD-DHDCSXOGSA-N
Smiles OC(C1=CC=C(C=C1)/C=C2SC(N(C/2=O)CC3=CC(C(F)(F)F)=CC=C3)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CY 09

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.47 20 with gentle warming

Preparing Stock Solutions for CY 09

The following data is based on the product molecular weight 423.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.81 mL 59.04 mL 118.08 mL
1 mM 2.36 mL 11.81 mL 23.62 mL
2 mM 1.18 mL 5.9 mL 11.81 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

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References for CY 09

References are publications that support the biological activity of the product.

Jiang et al (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 214 3219 PMID: 29021150

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Keywords: CY 09, CY 09 supplier, CY09, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, diabetes, anti-inflammatory, ATP, Inflammasomes, 6436, Tocris Bioscience

Citations for CY 09

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