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Description: TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
Purity: ≥95% (HPLC)
Biological Activity for D-GsMTx4
D-GsMTx4 is a TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.
Licensing Information
Sold under license from The Research Foundation of The State University of New York
Technical Data for D-GsMTx4
| M. Wt | 4095.86 |
| Formula | C185H273N49O45S6 |
| Sequence |
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: All aminoacids = D-aminoacids, Disulfide bridges: 2-17, 9-23, 16-30, Phe-34 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | WVDNTWXIIKNMHY-CFGROZRMSA-N |
| Smiles | CC(C)C[C@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H]2CSSC[C@@H](NC(=O)CN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]3CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC1=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(N)=O)NC3=O)C(=O)N2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for D-GsMTx4
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for D-GsMTx4
References for D-GsMTx4
References are publications that support the biological activity of the product.
Bae et al (2011) The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry 50 6295 PMID: 21696149
Alcaino et al (2017) Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 Channels (Austin) 11 245 PMID: 28085630
Maneshi et al (2018) Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Sci. Rep. 8 14267 PMID: 30250223
Gnanasambandam et al (2017) GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Biophys.J. 112 31 PMID: 28076814
If you know of a relevant reference for D-GsMTx4, please let us know.
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Keywords: D-GsMTx4, D-GsMTx4 supplier, TRPC, transient, receptor, potential, TRPC1, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors, venoms, piezo2, Piezo, Channels, 7170, Tocris Bioscience
Citations for D-GsMTx4
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