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Dapansutrile

Cat. No. 6902 1 Citation Submit a Review Datasheet / COA / SDS
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Description: NLRP3 inflammasome inhibitor; disrupts inflammasome formation
Chemical Name: 3-(Methylsulfonyl)propanenitrile
Purity: ≥98%
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Dapansutrile

Dapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.

OLT1177® is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.

Compound Libraries for Dapansutrile

Dapansutrile is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Dapansutrile

M. Wt 133.17
Formula C4H7NO2S
Storage Store at -20°C
Purity ≥98%
CAS Number 54863-37-5
PubChem ID 12714644
InChI Key LQFRYKBDZNPJSW-UHFFFAOYSA-N
Smiles C[S](=O)(=O)CCC#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Dapansutrile

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.32 100
ethanol 2.66 20

Preparing Stock Solutions for Dapansutrile

The following data is based on the product molecular weight 133.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.51 mL 37.55 mL 75.09 mL
5 mM 1.5 mL 7.51 mL 15.02 mL
10 mM 0.75 mL 3.75 mL 7.51 mL
50 mM 0.15 mL 0.75 mL 1.5 mL

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References for Dapansutrile

References are publications that support the biological activity of the product.

Marchetti et al (2018) OLT1177®, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc.Natl.Acad.Sci.USA. 115 E1530 PMID: 29378952

Marchetti et al (2018) NLRP3 inflammasome inhibitor OLT1177® suppresses joint inflammation in murine models of acute arthritis. Arthritis Res.Ther. 20 169 PMID: 30075804

Toldo et al (2019) The NLRP3 inflammasome inhibitor, OLT1177® (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse. J.Cardiovasc.Pharmacol. 73 215 PMID: 30747785

If you know of a relevant reference for Dapansutrile, please let us know.

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1 Citation for Dapansutrile

Citations are publications that use Tocris products. Selected citations for Dapansutrile include:

Michelle K et al (2023) Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19. iScience 26 106929 PMID: 37260746

Do you know of a great paper that uses Dapansutrile from Tocris? Please let us know.

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