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Submit ReviewDAU 5884 hydrochloride
Description: M3 receptor antagonist
Chemical Name: 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for DAU 5884 hydrochloride
DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.
Technical Data for DAU 5884 hydrochloride
| M. Wt | 351.83 |
| Formula | C17H21N3O3.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 131780-48-8 |
| PubChem ID | 16759154 |
| InChI Key | FDERDDSQHZRNGC-LIWIJTDLSA-N |
| Smiles | Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)N1CC2=C(NC1=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DAU 5884 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.59 | 50 | |
| DMSO | 35.18 | 100 |
Preparing Stock Solutions for DAU 5884 hydrochloride
The following data is based on the product molecular weight 351.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.21 mL | 28.42 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets for DAU 5884 hydrochloride
References for DAU 5884 hydrochloride
References are publications that support the biological activity of the product.
Doods et al (1993) Characterization of muscarinic receptors in guinea-pig uterus. Eur.J.Pharmacol. 250 223 PMID: 8112383
Roffel et al (1993) Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors. Eur.J.Pharmacol. 250 267 PMID: 8112384
Gosens et al (2003) Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am.J.Respir.Cell Mol.Biol. 28 257 PMID: 12540494
Gosens et al (2004) Muscarinic M3 receptor-dependent regulation of airway smooth muscle contractile phenotype. Br.J.Pharmacol. 141 943 PMID: 14993104
If you know of a relevant reference for DAU 5884 hydrochloride, please let us know.
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Keywords: DAU 5884 hydrochloride, DAU 5884 hydrochloride supplier, M3, receptor, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, DAU5884, hydrochloride, 2096, Tocris Bioscience
1 Citation for DAU 5884 hydrochloride
Citations are publications that use Tocris products. Selected citations for DAU 5884 hydrochloride include:
Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816
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Alzheimer's Disease Poster
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