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dBRD9-A

Cat. No. 6943 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Potent BRD9 Degrader (PROTAC®)
Chemical Name: 2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for dBRD9-A

dBRD9-A is a potent BRD9 Degrader (PROTAC®). Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model. BRD9 antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP3-14730.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for dBRD9-A

M. Wt 779.88
Formula C42H49N7O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2170679-42-0
PubChem ID 139370810
InChI Key ZDINQSNMYRVAGP-UHFFFAOYSA-N
Smiles COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCCCCCCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for dBRD9-A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 77.99 100
ethanol 7.8 10

Preparing Stock Solutions for dBRD9-A

The following data is based on the product molecular weight 779.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.41 mL 12.82 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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Reconstitution Calculator

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References for dBRD9-A

References are publications that support the biological activity of the product.

Brien et al (2018) Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife 7 e41305 PMID: 30431433

If you know of a relevant reference for dBRD9-A, please let us know.

View Related Products by Target

Keywords: dBRD9-A, dBRD9-A supplier, potent, selective, bromodomains, BRD9, active, degraders, degrades, PROTAC, PROTACs, sarcoma, targeted, protein, degradation, tpd, Bromodomains, Bromodomain, (BRD), Degraders, 6943, Tocris Bioscience

1 Citation for dBRD9-A

Citations are publications that use Tocris products. Selected citations for dBRD9-A include:

Nazar et al (2022) SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma. Nat Genet 54 861-873 PMID: 35681054

Do you know of a great paper that uses dBRD9-A from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia