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Submit Reviewdes-His1-[Glu9]-Glucagon (1-29) amide
Description: Glucagon receptor antagonist
Purity: ≥95% (HPLC)
Biological Activity for des-His1-[Glu9]-Glucagon (1-29) amide
des-His1-[Glu9]-Glucagon (1-29) amide is a glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.
Technical Data for des-His1-[Glu9]-Glucagon (1-29) amide
| M. Wt | 3358.68 |
| Formula | C148H221N41O47S |
| Sequence |
SQGTFTSEYSKYLDSRRAQDFVQWLMNT (Modifications: Thr-28 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 110084-95-2 |
| PubChem ID | 16133829 |
| InChI Key | RVXSASLSNHDASC-OSWDIKPLSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for des-His1-[Glu9]-Glucagon (1-29) amide
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for des-His1-[Glu9]-Glucagon (1-29) amide
References for des-His1-[Glu9]-Glucagon (1-29) amide
References are publications that support the biological activity of the product.
Unson et al (1989) Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10 1171 PMID: 2560175
Huypens et al (2000) Glucagon receptors on human islet cells contribute to glucose competence of Ins release. Diabetologia 43 1012 PMID: 10990079
Unson et al (1987) Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA 84 4083
If you know of a relevant reference for des-His1-[Glu9]-Glucagon (1-29) amide, please let us know.
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Keywords: des-His1-[Glu9)-Glucagon (1-29) amide, des-His1-[Glu9)-Glucagon (1-29) amide supplier, Glucagon, receptor, antagonists, antagonist, receptors, Receptor, 2216, Tocris Bioscience
1 Citation for des-His1-[Glu9]-Glucagon (1-29) amide
Citations are publications that use Tocris products. Selected citations for des-His1-[Glu9]-Glucagon (1-29) amide include:
Weston et al (2015) Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). Acta Pharmacol Sin 290 23009 PMID: 26198634
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.