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Submit ReviewDETA NONOate
Description: Nitric oxide donor
Chemical Name: 2,2'-(2-Hydroxy-2-nitrosohydrazinylidene)bis-ethanamine
Biological Activity for DETA NONOate
Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.
Technical Data for DETA NONOate
| M. Wt | 163.18 |
| Formula | C4H13N5O2 |
| Storage | Store at -20°C |
| CAS Number | 146724-94-9 |
| PubChem ID | 1606 |
| InChI Key | HMRRJTFDJAVRMR-UHFFFAOYSA-N |
| Smiles | NCCN(N(N=O)O)CCN |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DETA NONOate
References for DETA NONOate
References are publications that support the biological activity of the product.
Thompson et al (2009) The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br.J.Pharmacol. 158 1338 PMID: 19785659
Olson et al (1997) Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29 254 PMID: 9039111
Wegener et al (2002) Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 136 415 PMID: 12023944
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Keywords: DETA NONOate, DETA NONOate supplier, nitric, oxide, releasing, compounds, donors, NO, Donors, /, Precursors, ROS, 6077, Tocris Bioscience
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