Diltiazem hydrochloride

Cat. No. 0685 5 Citations Submit a Review Datasheet / COA / SDS

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Description: Ca_V1.x blocker

Chemical Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Diltiazem hydrochloride

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent; an inhibitor of L-type Ca²⁺ channels.

Compound Libraries for Diltiazem hydrochloride

Diltiazem hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Diltiazem hydrochloride

M. Wt	450.98
Formula	C₂₂H₂₆N₂O₄S.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	33286-22-5
PubChem ID	62920
InChI Key	HDRXZJPWHTXQRI-BHDTVMLSSA-N
Smiles	[H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Diltiazem hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		100
	DMSO	45.1	100

Preparing Stock Solutions for Diltiazem hydrochloride

The following data is based on the product molecular weight 450.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.09 mL	22.17 mL
5 mM	0.44 mL	2.22 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Product Datasheets for Diltiazem hydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Diltiazem hydrochloride

References are publications that support the biological activity of the product.

Dagani et al (1989) Effects of dilt. on bioenergetics, K⁺ gradients, and free cytosolic Ca²⁺ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379 PMID: 2795006

Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 118 1301 PMID: 8818357

Ishibashi et al (1995) Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 695 88 PMID: 8574653

Kraus et al (1998) Molecular mechanisms of dilt. interaction with L-type Ca²⁺ channels. J.Biol.Chem. 273 27205 PMID: 9765241

Merck Index 12 3247

If you know of a relevant reference for Diltiazem hydrochloride, please let us know.

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Keywords: Diltiazem hydrochloride, Diltiazem hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, anti-hypertensive, cardioprotective, Cav1.x, 0685, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Diltiazem hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov