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Submit ReviewDiMNF
Description: Selective aryl hydrocarbon receptor modulator (SAhRM)
Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Purity: ≥99% (HPLC)
Biological Activity for DiMNF
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.
Technical Data for DiMNF
| M. Wt | 332.35 |
| Formula | C21H16O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 14756-24-2 |
| PubChem ID | 276138 |
| InChI Key | QDZQDIUUJDAORK-UHFFFAOYSA-N |
| Smiles | O=C2C=C(C4=CC(OC)=C(OC)C=C4)OC1=C3C(C=CC=C3)=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DiMNF
References for DiMNF
References are publications that support the biological activity of the product.
Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545 PMID: 22235307
Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508 PMID: 21127131
Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345 PMID: 22553215
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Keywords: DiMNF, DiMNF supplier, DiMNF, aryl, hydrocarbon, receptors, AhRs, modulators, SAhRMs, anti-inflammatories, anti-inflammatory, Aryl, Hydrocarbon, Receptors, 4628, Tocris Bioscience
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