Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDiprenorphine
Description: Non-selective opioid antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Purity: ≥99% (HPLC)
Biological Activity for Diprenorphine
Diprenorphine is a non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors).
Technical Data for Diprenorphine
| M. Wt | 425.56 |
| Formula | C26H35NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 14357-78-9 |
| PubChem ID | 443408 |
| InChI Key | OIJXLIIMXHRJJH-KNLIIKEYSA-N |
| Smiles | OC1=CC=C3C2=C1O[C@@H]([C@]7(OC)[C@@H]([C@@](C)(O)C)C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Diprenorphine
References for Diprenorphine
References are publications that support the biological activity of the product.
Paterson et al (1983) Classification of opioid receptors. Br.Med.Bull. 39 31 PMID: 6301606
Raynor et al (1994) Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol.Pharmacol. 45 330 PMID: 8114680
Iwasaki et al (1994) The effect of the nonselective opioid antagonist diprenorphine vasopressin secretion in the rat. Endocrinology 134 48 PMID: 8275962
View Related Products by Target
View Related Products by Product Action
Keywords: Diprenorphine, Diprenorphine supplier, Non-Selective, opioids, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, 2965, Tocris Bioscience
1 Citation for Diprenorphine
Citations are publications that use Tocris products. Selected citations for Diprenorphine include:
Gardner et al (2015) Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Am J Physiol Cell Physiol 309 C491 PMID: 26246429
Reviews for Diprenorphine
Average Rating: 5 (Based on 1 Review.)
Have you used Diprenorphine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Diprenorphine in binding experiment.
By
Anonymous on 01/13/2020
Assay Type: In Vitro
Species: Human
Diprenorphine was use to displace radiolabeled-diprenorphine in an homologous radiobinding assay.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.