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Submit ReviewDL-AP3
Discontinued Product
0125 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Group I mGlu antagonist; also phosphoserine phosphatase inhibitor
Chemical Name: DL-2-Amino-3-phosphonopropionic acid
Biological Activity for DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
Technical Data for DL-AP3
| M. Wt | 169.07 |
| Formula | C3H8NO5P |
| Storage | Store at RT |
| CAS Number | 5652-28-8 |
| PubChem ID | 3857 |
| InChI Key | LBTABPSJONFLPO-UHFFFAOYSA-N |
| Smiles | NC(CP(O)(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DL-AP3
References for DL-AP3
References are publications that support the biological activity of the product.
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
Hawkinson et al (1996) The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 307 219 PMID: 8832224
Saugstad et al (1995) L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes. Eur.J.Pharmacol. 289 395 PMID: 7621916
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Keywords: DL-AP3, DL-AP3 supplier, Phosphoserine, phosphatase, inhibitors, inhibits, Group, I, mGlur, antagonists, Protein, Ser/Thr, Phosphatases, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, 20263-06-3, (Metabotropic), 0125, Tocris Bioscience
1 Citation for DL-AP3
Citations are publications that use Tocris products. Selected citations for DL-AP3 include:
Vance et al (2015) PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci 35 776 PMID: 25589770
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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