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Description: Partial NMDA agonist, acts glycine site
Chemical Name: (RS)-3-Amino-1-hydroxypyrrolidin-2-one
Biological Activity for (±)-HA-966
The overall effect of this much-investigated compound is the result of the actions of the two enantiomers: glycine-NMDA antagonism by the (+)-isomer and sedative and ataxic effects of the (-)-isomer. See separate isomers 0281 and 0282.
Technical Data for (±)-HA-966
| M. Wt | 116.12 |
| Storage | Store at RT |
| CAS Number | 1003-51-6 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-HA-966
Certificate of Analysis is currently unavailable on-line.
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References for (±)-HA-966
References are publications that support the biological activity of the product.
Evans et al (1978) Mg2+-like selective antagonism of excitatory amino acid - induced responses by α,ε-diaminopimelic acid, D-α-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat. Brain Res. 148 536 PMID: 207392
Foster and Kem (1989) HA-966 antagonises NMDA receptors through a selective interaction with the glycine modulatory site. J.Neurosci. 9 2191 PMID: 2542488
Lodge (1989) Non-competitive NMDA antagonists. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 37
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Keywords: (±)-HA-966, (±)-HA-966 supplier, NMDA, Receptors, 0198, Tocris Bioscience
Citations for (±)-HA-966
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Currently there are no citations for (±)-HA-966.
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