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Discontinued Product
3272 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Mixed mGlu2 agonist/ mGlu3 antagonist
Chemical Name: (1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for (±)-LY 395756
(±)-LY 395756 is a selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors (Ki values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu2 and antagonist at mGlu3. Analog of LY 354740 (Cat. No. 3246).
Technical Data for (±)-LY 395756
| M. Wt | 199.21 |
| Formula | C9H13NO4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 852679-66-4 |
| PubChem ID | 11310142 |
| InChI Key | BQVZICWQBFTOJX-QNDZYWSYSA-N |
| Smiles | N[C@]1([C@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])[C@H](C)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-LY 395756
References for (±)-LY 395756
References are publications that support the biological activity of the product.
Dominguez et al (2005) Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J.Med.Chem. 48 3605 PMID: 15887967
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Keywords: (±)-LY 395756, (±)-LY 395756 supplier, LY395756, agonist, metabotropic, glutamate, ligand, receptor, receptors, mGlu2, mGlu3, Glutamate, (Metabotropic), Group, II, Receptors, 3272, Tocris Bioscience
2 Citations for (±)-LY 395756
Citations are publications that use Tocris products. Selected citations for (±)-LY 395756 include:
Wang et al (2013) Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. Mol Pain 8 e61787 PMID: 23593498
Johnson (2017) Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum. Neuropharmacology 117 114 PMID: 28159646
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.