Home / Pharmacology / GPCRs / 7-TM Receptors / Chemokine Receptors / Chemokine CXC Receptors / Chemokine CXC Receptor Antagonists / (±)-NBI 74330

(±)-NBI 74330

Cat. No. 4528 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective CXCR3 antagonist
Chemical Name: N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (±)-NBI 74330

(±)-NBI 74330 is a potent and selective CXCR3 antagonist; potently inhibits 125I-CXCL10 binding to CXCR3 (pKi = 8.13). Inhibits calcium mobilization in response to CXCL11 and CXCL10 in RBL cells. Exhibits no significant effect on chemotaxis induced by CXCR4 or CCR7. Displays a five-fold greater affinity for CXCR3 than (±)-AMG 487.

This product is racemic.

Compound Libraries for (±)-NBI 74330

(±)-NBI 74330 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for (±)-NBI 74330

M. Wt 605.58
Formula C32H27F4N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 473722-68-8
PubChem ID 10167713
InChI Key XMRGQUDUVGRCBS-UHFFFAOYSA-N
Smiles CCOC(C=C3)=CC=C3N2C(C1=CC=CN=C1N=C2C(N(CC4=CC=CN=C4)C(CC5=CC(C(F)(F)F)=C(F)C=C5)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-NBI 74330

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.28 50

Preparing Stock Solutions for (±)-NBI 74330

The following data is based on the product molecular weight 605.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.3 mL 16.51 mL 33.03 mL
2.5 mM 0.66 mL 3.3 mL 6.61 mL
5 mM 0.33 mL 1.65 mL 3.3 mL
25 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for (±)-NBI 74330

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for (±)-NBI 74330

References are publications that support the biological activity of the product.

Storelli et al (2007) Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists. Arch.Pharm. 340 281 PMID: 17562560

Verzijl et al (2008) Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors. J.Pharmacol.Exp.Ther. 325 544 PMID: 18270317

Heise et al (2005) Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J.Pharmacol.Exp.Ther. 313 1263 PMID: 15761110

If you know of a relevant reference for (±)-NBI 74330, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Chemokine CXC Receptor Antagonists

Keywords: (±)-NBI 74330, (±)-NBI 74330 supplier, VUF10472, (±)-NBI74330, potent, selective, CXCR3, antagonists, chemokines, (±)-NBI_74330, Chemokine, CXC, Receptors, 4528, Tocris Bioscience

1 Citation for (±)-NBI 74330

Citations are publications that use Tocris products. Selected citations for (±)-NBI 74330 include:

Piotrowska et al (2018) Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies. Biochim.Biophys.Acta 1864 3418 PMID: 30076959

Do you know of a great paper that uses (±)-NBI 74330 from Tocris? Please let us know.

Reviews for (±)-NBI 74330

There are currently no reviews for this product. Be the first to review (±)-NBI 74330 and earn rewards!

Have you used (±)-NBI 74330?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.