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Submit Review(±)-Vesamicol hydrochloride
Description: Inhibits ACh transport
Alternative Names: AH 5183
Chemical Name: (±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for (±)-Vesamicol hydrochloride
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.
Technical Data for (±)-Vesamicol hydrochloride
| M. Wt | 295.85 |
| Formula | C17H25NO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 120447-62-3 |
| PubChem ID | 659839 |
| InChI Key | XJNUHVMJVWOYCW-GBNZRNLASA-N |
| Smiles | O[C@@H]1CCCC[C@H]1N(CC3)CCC3C2=CC=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-Vesamicol hydrochloride
References for (±)-Vesamicol hydrochloride
References are publications that support the biological activity of the product.
Efange et al (1997) N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J.Med.Chem. 40 3905 PMID: 9397171
Kobayashi et al (1997) Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res.Bull. 43 17 PMID: 9205789
Varoqui and Erickson (1996) Active transport of acetylcholine by the human vesicular acetylcholine transporter. J.Biol.Chem. 271 27229 PMID: 8910293
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Keywords: (±)-Vesamicol hydrochloride, (±)-Vesamicol hydrochloride supplier, AH5183, inhibitors, inhibits, ACh, transport, Acetylcholine, Transporters, Monoamine, Neurotransmitter, AH, 5183, 0653, Tocris Bioscience
Citations for (±)-Vesamicol hydrochloride
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Currently there are no citations for (±)-Vesamicol hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.