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Description: LRH-1 agonist; regulates bile acid metabolism
Chemical Name: (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxododecyl)oxy]-3,5,9-trioxa-4-phosphaheneicosan-1-aminium-4-oxide
Biological Activity for DLPC
Selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.
Technical Data for DLPC
| M. Wt | 621.83 |
| Formula | C32H64NO8P |
| Storage | Store at -20°C |
| CAS Number | 18194-25-7 |
| PubChem ID | 512874 |
| InChI Key | IJFVSSZAOYLHEE-SSEXGKCCSA-N |
| Smiles | [O-]P(OC[C@H](OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)(OCC[N+](C)(C)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DLPC
References for DLPC
References are publications that support the biological activity of the product.
Lee et al (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474 506 PMID: 21614002
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Keywords: DLPC, DLPC supplier, Dilauroyl, phosphatidylcholine, LRH-1, agonist, orphan, nuclear, receptor, agonists, NR5A2, saturated, fatty, acid, chain, liver, homolog, homologue, Other, Nuclear, Receptors, Lipid, Metabolism, 4378, Tocris Bioscience
2 Citations for DLPC
Citations are publications that use Tocris products. Selected citations for DLPC include:
Zhu et al (2014) Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature 508 93 PMID: 24572354
Zimmerlin et al (2016) Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development 143 4368 PMID: 27660325
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